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KMID : 0603820100160010065
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Journal of Experimental & Biomedical Science
2010 Volume.16 No. 1 p.65 ~ p.67
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Expressional Variation of Endoplasmic Reticulum Stress Signaling Factors in Mouse Tissues by Aging
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Han Song-Yi
Jin Cho-Yi
Kwon Ki-Sang
Yun Eun-Young
Goo Tae-Won
Kim Seung-Hwan
Kwon O-Yu
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Abstract
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The endoplasmic reticulum (ER) is a multifunctional intercellular organelle in which several posttranslational modification steps occurred such as protein folding, lipid biosynthesis, calcium storage and release. Perturbations that disrupt ER homeostasis lead to the misfolding of proteins in the ER lumen and up-regulation of ER signaling pathway called the unfolded protein response (UPR). Here, we have demonstrated that ageing changes the expression of ER chaperone and associated ER membrane kinases of IRE1, ATF6 and PERK.
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KEYWORD
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Endoplasmic reticulum(ER) stress, ER chaperone, Aging
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